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KMID : 0369819910210020073
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Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 2 p.73 ~ p.78
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Study on the Design of Propranolol Rectal Suppository
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김가나/Kim GN
최준식/이진환/Choi JS/Lee JH
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Abstract
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The influence of different suppository bases on the rectal absorption and the dissolution rate of propranolol was investigated. The bioavailability of propranolol in rectal suppository was determined by comparing the area under the concentration-time curves(AUC) for oral administration with rectal suppositories in rabbits. The dissolution rates(D20min) were higher in such order as tween (TWE), witepsol H-15(WIT), polyethylene glycol(PEG) suppository. The maximum blood concentrations (Cmax) were 803.9 ng/ml for TWE suppository, 770.2 ng/ml for WIT suppository, 281.2 ng/ml for PEG suppository and 177.1 ng/ml for oral administration. The relative bioavailabilities were 233.5% for TWE suppository, 218.1% for TWE suppository, 191.3% for PEG suppository. The correlation between D20min and AUC, the time for dissolution in 75% and Cmax, the mean dissolution time and the mean residence time showed significant linear relationship respectively.
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KEYWORD
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propranolol suppository, rectal absorption, Tween, Witepiol H-15, polyethylene glycol, dissolution, relative bioavailability, relationship
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